Free express shipping when you spend $100+ on your purchase with code SHIP
FREE US Shipping $50+ Auto-Replenishment 15% off First App Order Dermstore Rewards
SkinMedica

SkinMedica Age Defense Retinol Complex .25 (1 fl. oz.)

A retinol-based, night lotion for first-time users of all skin types.

Rewards members earn 320 points on this order. Register & opt in at checkout.

Join Dermstore Rewards

$64.00

Or 4 interest free payments of $16.00 with


In stock | Usually dispatched within 24 hours

Image 1 - Three silver bottles of SkinMedica Retinol Complex product are shown with text Retinol Complex A Skincare Essential, Diminishes the appearance of sun damage fine lines and coarse wrinkles, Enhances skin tone texture and resiliency, Renews skin, 0.25, 0.5, and 1.0. Image 2 - A split image shows a womans face before and after treatment, with the left side showing redness and uneven tone and the right side showing improved tone and texture, with the text Before After BASELINE AFTER 12 WEEKS* 54 YEAR OLD FEMALE. UNRETOUCHED PHOTOS OF SUBJECT AT BASELINE AND 12 WEEKS AFTER USING RETINOL COMPLEX 0.25. *DATA ON FILE AT SKINMEDICA. Image 3 - A white cream texture is shown against a light brown background with the text Features PhytoShield™ Complex that encapsulates retinol for targeted delivery Helps to minimize the irritation typically associated with the use of retinol. Image 4 - Three silver pump bottles of SkinMedica Retinol Complex in strengths 1.0, 0.5, and 0.25 with text that says Pick Your Strength Suitable for all skin types and available in 3 strength levels If you are new to retinol, its recommended to begin with 0.25, then progress to 0.5 and 1.0. Image 5 - A hand holds a SkinMedica Retinol Complex 1.0 bottle next to text explaining how to use the product which reads How to Use WHEN TO APPLY In the evening after cleansing and toning, and before your moisturizer If you are new to retinol, begin twice a week, gradually increasing to each evening or as tolerated WHERE TO APPLY To your entire face, avoiding eyes Mild redness, peeling and irritation are expected when using this product. Use a daily sun protection with SPF 30 or higher and limit sun exposure while using this product, and for a week following discontinuation. The bottle text reads SkinMedica RETINOL COMPLEX 1.0 1 fl oz / 29.6 ml. Image 6 - An image displaying text explaining the benefits of glass packaging next to a product bottle with the text The Benefits of Glass Packaging Protection from Light Retinol is sensitive to light which can reduce its effectiveness Glass bottles protect from exposure to light Chemical Stability Glass minimizes potential chemical interactions between retinol and the packaging maintaining its stability and efficacy Preservation of Ingredients Glass better preserves active ingredients maintaining the retinols quality and extending its shelf life SkinMedica RETINOL COMPLEX 1.0 1 FL. OZ. / 29.6 mL. Image 7 - Image showing SkinMedica skincare products with the title Complete Your SkinMedica Method Routine followed by five steps 01 The Cleanse Factor AHA BHA Exfoliating Cleanser 02 The Growth Factor TNS Advanced+ Serum 03 The Correct Factor Retinol Complex 04 The Hydrate Factor HAS Hydra Collagen Replenish + Restore Hydrator 05 The Protect Factor Essential Defense Mineral Shield Broad Spectrum SPF 35 Sunscreen. Image 8 - A close-up of a smiling womans face with text overlay that reads Pioneer of regenerative skincare With over 25 years of innovation, SkinMedica develops professional-grade products for every step in a complete skincare routine.

Delivery & Returns
Free delivery is available on all orders over $50. Please see our shipping information page for all available delivery options.
If I'm not completely happy with my item?
Please see our returns policy.
*points earned on final checkout price, after any applied discounts.

Frequently Bought Together

SkinMedica Age Defense Retinol Complex .25 (1 fl. oz.)

This item

SkinMedica Age Defense Retinol Complex .25 (1 fl. oz.)

$64.00

Total Price:

$144.00

Other Customers Bought

Customer Reviews

4.79 stars out of a maximum of 5

5 stars rating 235 reviews

4 stars rating 29 reviews

3 stars rating 4 reviews

2 stars rating 3 reviews

1 stars rating 3 reviews

Top Customer Reviews

Reviews and results may vary from person to person. Customer reviews are and do not represent the views of The Hut Group.

Skin medica retinol

5 stars out of a maximum of 5

This retinol serum is really nice bc I've used slit of harsh retinol that turn my skin red , but this serum is gentle enough that I can use it almost every night as part of my skin regimen. Oh , and it smells fresh not super strong!

by Michele

Was this helpful?

Great First Time Retinol

5 stars out of a maximum of 5

I have never used Retinol before and started with this product. I have very sensitive and acne prone skin and this product has not caused any redness or irritation ever since I started using. I started using twice a week and now use every other night and still never experience any redness/dryness from using this. I wake up with my skin feeling extremely soft after each use. I would definitely buy again and possibly go for the .5 next time.

by Anonymous Verified Purchase

Was this helpful?

Very gentle

5 stars out of a maximum of 5

I have moderately sensitive skin and have never had irritation from this product. I can use it daily without issue. I definitely noticed my deep forehead wrinkles are way less deep lately.

by Anonymous Verified Purchase

Was this helpful?

My Favorite Retinol

5 stars out of a maximum of 5

I love this product. It is very gentle. I never had irritation and was able to use it every night from the beginning. When I run out of this strength, I will purchase the next one up!

by Anonymous Verified Purchase

Was this helpful?

Great for my sensitive skin

5 stars out of a maximum of 5

This is the only retinol product that I have found that does not irritate my sensitive skin. I have been using it for three years now and still love it.

by Anonymous Verified Purchase

Was this helpful?

No irritation

5 stars out of a maximum of 5

I have used many different retin-A creams. This is the first one that does not cause redness, irritation and sensitivity. I started out using once a week. Now I am using twice. My skin is looking like a babies. Pores are smaller and the texture is smoother not rough. I am very happy with the product.

by Anonymous Verified Purchase

Was this helpful?

Great skin care routine addition

5 stars out of a maximum of 5

I was recently recommended to add retinol into my skincare regimen for my aging 50s skin. So far I have loved the results! I can tell my skin elasticity and firmness has gotten better. Will continue to use and go up in percentage as I go through the product.

by Amy Verified Purchase

Was this helpful?

Amazing!!!!!

5 stars out of a maximum of 5

This product is a game changer. I will never not have this part of my skin care routine!

by Anonymous Verified Purchase

Was this helpful?

First Experience with Retinol

5 stars out of a maximum of 5

This is the first retinol I have purchased, so I started off with 0.25. It is very gentle, and I am able to use it nightly with no issues after only a week. There was minor stinging/sensitivity the first time I used it, but nothing since. I've already noticed a positive change in the texture of my skin, so I can't wait to see what long term changes are! I am planning to upgrade to 0.5 when this bottle runs out. Great product!

by Anonymous Verified Purchase

Was this helpful?

good product

4 stars out of a maximum of 5

I enjoy this product, easy to apply, not greasy with no smell. It did not irritate my skin at all and I was using it every other day. I am going to purchase the .5 next

by Anonymous Verified Purchase

Was this helpful?

Powered by firmly · Terms · Privacy